Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2)
Identifieur interne : 002250 ( Main/Exploration ); précédent : 002249; suivant : 002251Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2)
Auteurs : Nancy J. Cox [États-Unis] ; Fumio Kitame [Japon] ; Alan P. Kendal [États-Unis] ; Hunein F. Maassab [États-Unis] ; Clayton Naeve [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1988.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN viral (génétique), Basse température, Capside (génétique), DNA-directed RNA polymerases (génétique), Données de séquences moléculaires, Gènes viraux, Protéines de la matrice virale (génétique), Protéines du core viral (génétique), Protéines virales (génétique), Protéines virales non structurales, Ribonucléoprotéines (génétique), Sous-type H2N2 du virus de la grippe A, Séquence d'acides aminés, Séquence nucléotidique, Vaccins antigrippaux (génétique), Vaccins atténués (génétique), Virus de la grippe A (génétique).
- MESH :
- Pascal (Inist)
- Basse température, Données de séquences moléculaires, Froid, Gènes viraux, Influenzavirus A, Protéines virales non structurales, Sensibilité résistance, Souche atténuée, Souche vaccinale, Sous-type H2N2 du virus de la grippe A, Séquence d'acides aminés, Séquence nucléotide, Séquence nucléotidique, Vaccin.
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
- Amino Acid Sequence, Attenuated strain, Base Sequence, Capsid (genetics), Cold, Cold Temperature, DNA-Directed RNA Polymerases (genetics), Genes, Viral, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza Vaccines (genetics), Influenzavirus A, Molecular Sequence Data, Nucleotide sequence, RNA, Messenger (genetics), RNA, Viral (genetics), Ribonucleoproteins (genetics), Sensitivity resistance, Vaccine, Vaccine strain, Vaccines, Attenuated (genetics), Viral Core Proteins (genetics), Viral Matrix Proteins (genetics), Viral Nonstructural Proteins, Viral Proteins (genetics).
- MESH :
- chemical , genetics : DNA-Directed RNA Polymerases, Influenza Vaccines, RNA, Messenger, RNA, Viral, Ribonucleoproteins, Vaccines, Attenuated, Viral Core Proteins, Viral Matrix Proteins, Viral Proteins.
- genetics : Capsid, Influenza A virus.
- Amino Acid Sequence, Base Sequence, Cold Temperature, Genes, Viral, Influenza A Virus, H2N2 Subtype, Molecular Sequence Data, Viral Nonstructural Proteins.
- Teeft :
- Acad, Amino, Amino acid, Amino acid changes, Amino acid substitution, Amino acid substitutions, Amino acids, Attenuated, Attenuated influenza, Attenuated influenza vaccines, Attenuated vaccines, Attenuation, Coding, Coding change, Coding changes, Comparative studies, Complete nucleotide sequences, Dideoxy chain termination method, Donor virus, Encodes, First nucleotide, Gene, Gene sequences, Genetic stability, Genome, Glutamic acid, Human influenza, Human volunteers, Influenza, Influenza virus, Influenza viruses, Kendal, Maassab, Mutant, Mutant viruses, Mutation, Noncoding, Noncoding change, Noncoding changes, Noncoding region, Nucleic, Nucleic acids, Nucleotide, Nucleotide changes, Nucleotide differences, Nucleotide sequence, Nucleotide sequences, Oligonucleotide mapping, Personal communication, Phenotypic, Phenotypic properties, Polymerase, Primer, Proc, Reassortant, Reassortants, Recombinant, Same codon, Sequencing, Seronegative, Single gene reassortants, Substitution, Total number, Vaccine, Viral, Virol, Virology, Virus.
Abstract
Abstract: Nucleotide sequences have been obtained for RNA segments encoding the PB2, P131, PA, NP, M1, M2, NS1, and NS2 proteins of the influenza A/Ann Arbor/6/60 (H2N2) wild-type (wt) virus and its cold-adapted (ca) derivative that has been used for preparing investigational live attenuated vaccines. Twenty-four nucleotide differences between the ca and wt viruses were detected, of which 11 were deduced to code for amino acid substitutions in the ca virus proteins. One amino acid substitution each was predicted for the PB2, M2, and NS1 proteins. Two amino acid substitutions were predicted for the NP and the PA proteins. Four substitutions were predicted for the PB1 protein. The biological significance of mutations in the PB2, PB1, PA, and M2 genes of the ca virus is suggested by currently available genetic data, a comparison with other available influenza gene sequences, and the nature of the predicted amino acid changes. In addition, the sequence data confirm the close evolutionary relationship between the genomes of influenza A (H2N2) and influenza A (H3N2) viruses.
Url:
DOI: 10.1016/0042-6822(88)90118-3
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000184
- to stream Istex, to step Curation: 000184
- to stream Istex, to step Checkpoint: 000F63
- to stream Main, to step Merge: 002358
- to stream PascalFrancis, to step Corpus: 000115
- to stream PascalFrancis, to step Curation: 000099
- to stream PascalFrancis, to step Checkpoint: 000116
- to stream Main, to step Merge: 002378
- to stream PubMed, to step Corpus: 000468
- to stream PubMed, to step Curation: 000468
- to stream PubMed, to step Checkpoint: 000418
- to stream Ncbi, to step Merge: 000E74
- to stream Ncbi, to step Curation: 000E74
- to stream Ncbi, to step Checkpoint: 000E74
- to stream Main, to step Merge: 002303
- to stream Main, to step Curation: 002250
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2)</title>
<author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name>
</author>
<author><name sortKey="Kitame, Fumio" sort="Kitame, Fumio" uniqKey="Kitame F" first="Fumio" last="Kitame">Fumio Kitame</name>
</author>
<author><name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name>
</author>
<author><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name>
</author>
<author><name sortKey="Naeve, Clayton" sort="Naeve, Clayton" uniqKey="Naeve C" first="Clayton" last="Naeve">Clayton Naeve</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5D8FD6687FDADE5986AA6FD2FE7C09B909341E23</idno>
<date when="1988" year="1988">1988</date>
<idno type="doi">10.1016/0042-6822(88)90118-3</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-L43VRGN7-H/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000184</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000184</idno>
<idno type="wicri:Area/Istex/Curation">000184</idno>
<idno type="wicri:Area/Istex/Checkpoint">000F63</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000F63</idno>
<idno type="wicri:doubleKey">0042-6822:1988:Cox N:identification:of:sequence</idno>
<idno type="wicri:Area/Main/Merge">002358</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:89-0247753</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000115</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000099</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000116</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000116</idno>
<idno type="wicri:doubleKey">0042-6822:1988:Cox N:identification:of:sequence</idno>
<idno type="wicri:Area/Main/Merge">002378</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:2974219</idno>
<idno type="wicri:Area/PubMed/Corpus">000468</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000468</idno>
<idno type="wicri:Area/PubMed/Curation">000468</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000468</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000418</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000418</idno>
<idno type="wicri:Area/Ncbi/Merge">000E74</idno>
<idno type="wicri:Area/Ncbi/Curation">000E74</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000E74</idno>
<idno type="wicri:doubleKey">0042-6822:1988:Cox N:identification:of:sequence</idno>
<idno type="wicri:Area/Main/Merge">002303</idno>
<idno type="wicri:Area/Main/Curation">002250</idno>
<idno type="wicri:Area/Main/Exploration">002250</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2)</title>
<author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Influenza Branch, Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333</wicri:regionArea>
<wicri:noRegion>Georgia 30333</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kitame, Fumio" sort="Kitame, Fumio" uniqKey="Kitame F" first="Fumio" last="Kitame">Fumio Kitame</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Bacteriology, Yamagata University, School of Medicine, Zao-lida, Yamagata 990-23</wicri:regionArea>
<wicri:noRegion>Yamagata 990-23</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Influenza Branch, Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333</wicri:regionArea>
<wicri:noRegion>Georgia 30333</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48104</wicri:regionArea>
<wicri:noRegion>Michigan 48104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Naeve, Clayton" sort="Naeve, Clayton" uniqKey="Naeve C" first="Clayton" last="Naeve">Clayton Naeve</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Virology, St. Jude Children's Hospital for Research, 322 N. Lauderdale, Memphis, TN 38101</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Virology</title>
<title level="j" type="abbrev">YVIRO</title>
<idno type="ISSN">0042-6822</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1988">1988</date>
<biblScope unit="volume">167</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="554">554</biblScope>
<biblScope unit="page" to="567">567</biblScope>
</imprint>
<idno type="ISSN">0042-6822</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0042-6822</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Attenuated strain</term>
<term>Base Sequence</term>
<term>Capsid (genetics)</term>
<term>Cold</term>
<term>Cold Temperature</term>
<term>DNA-Directed RNA Polymerases (genetics)</term>
<term>Genes, Viral</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza Vaccines (genetics)</term>
<term>Influenzavirus A</term>
<term>Molecular Sequence Data</term>
<term>Nucleotide sequence</term>
<term>RNA, Messenger (genetics)</term>
<term>RNA, Viral (genetics)</term>
<term>Ribonucleoproteins (genetics)</term>
<term>Sensitivity resistance</term>
<term>Vaccine</term>
<term>Vaccine strain</term>
<term>Vaccines, Attenuated (genetics)</term>
<term>Viral Core Proteins (genetics)</term>
<term>Viral Matrix Proteins (genetics)</term>
<term>Viral Nonstructural Proteins</term>
<term>Viral Proteins (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term>
<term>ARN viral (génétique)</term>
<term>Basse température</term>
<term>Capside (génétique)</term>
<term>DNA-directed RNA polymerases (génétique)</term>
<term>Données de séquences moléculaires</term>
<term>Gènes viraux</term>
<term>Protéines de la matrice virale (génétique)</term>
<term>Protéines du core viral (génétique)</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales non structurales</term>
<term>Ribonucléoprotéines (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Vaccins antigrippaux (génétique)</term>
<term>Vaccins atténués (génétique)</term>
<term>Virus de la grippe A (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Directed RNA Polymerases</term>
<term>Influenza Vaccines</term>
<term>RNA, Messenger</term>
<term>RNA, Viral</term>
<term>Ribonucleoproteins</term>
<term>Vaccines, Attenuated</term>
<term>Viral Core Proteins</term>
<term>Viral Matrix Proteins</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Capsid</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term>
<term>ARN viral</term>
<term>Capside</term>
<term>DNA-directed RNA polymerases</term>
<term>Protéines de la matrice virale</term>
<term>Protéines du core viral</term>
<term>Protéines virales</term>
<term>Ribonucléoprotéines</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Base Sequence</term>
<term>Cold Temperature</term>
<term>Genes, Viral</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Molecular Sequence Data</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Basse température</term>
<term>Données de séquences moléculaires</term>
<term>Froid</term>
<term>Gènes viraux</term>
<term>Influenzavirus A</term>
<term>Protéines virales non structurales</term>
<term>Sensibilité résistance</term>
<term>Souche atténuée</term>
<term>Souche vaccinale</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotide</term>
<term>Séquence nucléotidique</term>
<term>Vaccin</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acad</term>
<term>Amino</term>
<term>Amino acid</term>
<term>Amino acid changes</term>
<term>Amino acid substitution</term>
<term>Amino acid substitutions</term>
<term>Amino acids</term>
<term>Attenuated</term>
<term>Attenuated influenza</term>
<term>Attenuated influenza vaccines</term>
<term>Attenuated vaccines</term>
<term>Attenuation</term>
<term>Coding</term>
<term>Coding change</term>
<term>Coding changes</term>
<term>Comparative studies</term>
<term>Complete nucleotide sequences</term>
<term>Dideoxy chain termination method</term>
<term>Donor virus</term>
<term>Encodes</term>
<term>First nucleotide</term>
<term>Gene</term>
<term>Gene sequences</term>
<term>Genetic stability</term>
<term>Genome</term>
<term>Glutamic acid</term>
<term>Human influenza</term>
<term>Human volunteers</term>
<term>Influenza</term>
<term>Influenza virus</term>
<term>Influenza viruses</term>
<term>Kendal</term>
<term>Maassab</term>
<term>Mutant</term>
<term>Mutant viruses</term>
<term>Mutation</term>
<term>Noncoding</term>
<term>Noncoding change</term>
<term>Noncoding changes</term>
<term>Noncoding region</term>
<term>Nucleic</term>
<term>Nucleic acids</term>
<term>Nucleotide</term>
<term>Nucleotide changes</term>
<term>Nucleotide differences</term>
<term>Nucleotide sequence</term>
<term>Nucleotide sequences</term>
<term>Oligonucleotide mapping</term>
<term>Personal communication</term>
<term>Phenotypic</term>
<term>Phenotypic properties</term>
<term>Polymerase</term>
<term>Primer</term>
<term>Proc</term>
<term>Reassortant</term>
<term>Reassortants</term>
<term>Recombinant</term>
<term>Same codon</term>
<term>Sequencing</term>
<term>Seronegative</term>
<term>Single gene reassortants</term>
<term>Substitution</term>
<term>Total number</term>
<term>Vaccine</term>
<term>Viral</term>
<term>Virol</term>
<term>Virology</term>
<term>Virus</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Nucleotide sequences have been obtained for RNA segments encoding the PB2, P131, PA, NP, M1, M2, NS1, and NS2 proteins of the influenza A/Ann Arbor/6/60 (H2N2) wild-type (wt) virus and its cold-adapted (ca) derivative that has been used for preparing investigational live attenuated vaccines. Twenty-four nucleotide differences between the ca and wt viruses were detected, of which 11 were deduced to code for amino acid substitutions in the ca virus proteins. One amino acid substitution each was predicted for the PB2, M2, and NS1 proteins. Two amino acid substitutions were predicted for the NP and the PA proteins. Four substitutions were predicted for the PB1 protein. The biological significance of mutations in the PB2, PB1, PA, and M2 genes of the ca virus is suggested by currently available genetic data, a comparison with other available influenza gene sequences, and the nature of the predicted amino acid changes. In addition, the sequence data confirm the close evolutionary relationship between the genomes of influenza A (H2N2) and influenza A (H3N2) viruses.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
<li>États-Unis</li>
</country>
<region><li>Tennessee</li>
</region>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name>
</noRegion>
<name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name>
<name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name>
<name sortKey="Naeve, Clayton" sort="Naeve, Clayton" uniqKey="Naeve C" first="Clayton" last="Naeve">Clayton Naeve</name>
</country>
<country name="Japon"><noRegion><name sortKey="Kitame, Fumio" sort="Kitame, Fumio" uniqKey="Kitame F" first="Fumio" last="Kitame">Fumio Kitame</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002250 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002250 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:5D8FD6687FDADE5986AA6FD2FE7C09B909341E23 |texte= Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2) }}
This area was generated with Dilib version V0.6.33. |